Late goals in both halves consigned us to our first pre-season defeat of the summer.
Eiran Cashin nodded Derby ahead from a corner shortly before the interval, with Tom Lawrence adding gloss to the scoreline with a second-half penalty.
Kyle Wootton had been unable to convert two well-worked opportunities with the score at 1-0 and there were plenty of promising performances as Ian Burchnall's men continued their 2021-22 preparations with a competitive performance against the Sky Bet Championship side.
Notts starting XI: Slocombe; Cameron, Rawlinson (McGregor 86'), Brindley; Taylor (Chicksen 46'), Kelly-Evans (Nemane 76'); Francis, Palmer, O'Brien (Hondermarck 76'); Roberts (Sam 62'), Wootton
Unused subs: Brooks